The Mousetrap will reopen in the West End with two separate casts.
Socially distanced West End performances of the play will resume at St Martins Theatre in May with tickets on sale now.
After performances were halted last March amid lockdown restrictions, the show has announced plans to start again from May 17.
Shows will feature two alternating eight-member casts to ensure the show can go on.
One cast features Cassidy Janson (Mollie Ralston), Danny Mac (Giles Ralston), Alexander Wolfe (Christopher Wren), Susan Penhaligon (Mrs Boyle), Derek Griffiths (Major Metcalf), Lizzie Muncey (Miss Casewell), David Rintoul (Mr Paravicini) and Paul Hilliar (Detective Sergeant Trotter).
The second cast stars Kate Tydman (Mollie Ralston), Nicholas Bailey (Giles Ralston), Joshua Griffin (Christopher Wren), Louise Jameson (Mrs Boyle), Paul Bradley (Major Metcalf), Sarah Moss (Miss Casewell), Tony Timberlake (Mr Paravicini) and Charlie Clements (Detective Sergeant Trotter).
Details on cast schedules can be found on the official Mousetrap website here.
Adam Spiegel, the producer of The Mousetrap, said: “I am thrilled today to announce the award winning company of actors that have assembled to lead The Mousetrap back to the West End.
“The production is an enduring symbol of London theatre and I hope that its return signifies the first steps in the restoration of live theatre in London. I am so pleased that these hugely accomplished performers have chosen to participate in this historic moment.”
The Mousetrap is famous around the world for being the longest running show of any kind in the history of British theatre.
The Mousetrap is the iconic murder mystery play. The scene is set when a group of people gathered in a country house cut off by the snow discover, to their horror, that there is a murderer in their midst. Who can it be? One by one the suspicious characters reveal their sordid pasts until at the last, nerve-shredding moment the identity and the motive are finally revealed.
In her own inimitable style, Dame Agatha Christie has created an atmosphere of shuddering suspense and a brilliantly intricate plot where murder lurks around every corner.