Come From Away has suspended performances in London's West End until June 2021.
The news means the planned special concert production due to run in February has been cancelled.
It comes as the Ambassador Theatre Group (ATG), owners of the Phoenix Theatre where Come From Away is currently home, suspends all shows until at least 3 April 2021.
A statement from Come From Away reads: "Due to ongoing government restrictions, and following Ambassador Theatre Group's announcement today, performances of Come From Away at the Phoenix Theatre are suspended until Friday 18 June 2021.
"As a result, we have sadly had to make the decision to cancel Come From Away: The Concert.
"If you have booked for the concert, your booking will be reallocated to the full production with your tickets honoured at the price of your original seats. ATG will contact all affected ticket holders regarding exchanges or refunds.
"If you have booked for the show between 8 March and 18 June 2021, the box office or retailer from whom you bought your tickets will be in contact with you directly regarding your booking.
We can't wait to welcome you back to the rock as soon as we can!"
Critically acclaimed and award winning musical Come From Away shares the touching real-life story of the 7,000 air passengers from all over the world who were grounded in Canada during the wake of the 9/11 terror attacks, and the small Newfoundland community that invited these ‘come from aways’ into their lives.
Awarded the 2019 Olivier for Best New Musical and the Tony for Best Direction of a Musical, Christopher Ashley's production guides audiences through a colourful and spirited cast of characters, brought to life by the multi-award winning writing team of Irene Sankoff and David Hein.
The current cast features Jenna Boyd (Beulah and others), Tarinn Callender (Bob and others), James Doherty (Claude and others), Mary Doherty (Bonnie and others), Mark Dugdale (Kevin T/Garth and others), Alice Fearn (Beverley/Annette and others), Kate Graham (Diane and others), Alasdair Harvey (Nick/Doug and others), Jonathan Andrew Hume (Kevin J/Ali and others), Harry Morrison (Oz and others), Emma Salvo (Janice and others), and Cat Simmons (Hannah and others), with Ricardo Castro, Stuart Hickey, Sorelle Marsh, Alexander McMorran, Micha Richardson, Jennifer Tierney and Matthew Whennell-Clark.