Sara Bareilles and Gavin Creel are to leave the cast of Waitress in London's West End on March 14.
The pair have been appearing in the roles of Jenna and Dr Pomatter since January 27.
Originally due to play through to March 7, they had extended their run through to March 21.
However in a statement shared on social media today (March 13), the pair announced that they would be departing the show following Saturday's evening performance on March 14.
Bareilles wrote: "Dearest Waitress Fans, It is with a heavy heart that I write this letter to inform you that Gavin and I will be playing our final performance the evening of March 14.
"Given the recent international travel restrictions, we've made the very difficult decision, before any further measures are implemented, to return home.
"It was an agonizing choice as we have so loved our time here at the Adelphi diner. The warmth and generosity of the West End audiences has been unparalleled. It was a gift to get the opportunity to tell this story again alongside this masterful cast, crew and band. We will miss you all dearly.
"Sugar Butter London Forever, Sara and Gavin."
Bareilles wrote the score for the musical and previously appeared in the lead role on Broadway alongside Creel last year.
Bareilles is making her West End debut in the show while Creel previously appeared in the London casts of Mary Poppins and The Book of Mormon.
They replaced Lucie Jones and David Hunter in the roles in London. The cast from Monday, March 16, has yet to be confirmed.
Waitress tells the story of Jenna a waitress and expert pie-maker who dreams of a way out of her small town and rocky marriage.
Waitress in London recently announced its final performance for July 4 ahead of a UK tour opening in Dublin later in 2020.